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Showing posts with label kidney damage. Show all posts
Showing posts with label kidney damage. Show all posts

2013/06/25

What does "Traceable to IDMS" mean ?

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all laboratories should now be using a creatinine method that has been standardized or traceable to isotope dilution mass spectrometry (IDMS). The way creatinine levels are calibrated affects the GFR estimating equation slightly.
to properly estimate GFR, the serum creatinine must be measured accurately. When a laboratory calibrates their method to the single standardized serum creatinine using reference materials traceable to the primary reference material at the National Institute of Standards, we say that value is traceable to IDMS because the test is based on isotope dilution mass spectrometry (IDMS).
with the exception of the Cockcroft-Gault formula, all other calculators in this Smartphone application are designed for use with standardized creatinine values that are traceable to IDMS. Also, only standardized cystatin C values are used.
your laboratory can confirm whether or not it uses standardized creatinine values that are traceable to IDMS. It can also confirm whether it uses cystatin C values that are standardized.

Why use GFR as a measure of kidney function ?

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Normal GFR varies according to age, sex, and body size; in young adults it is approximately 120-130 mL/min/1.73m2 and declines normally with age. However, a decrease in GFR may also be a marker of kidney disease and precedes the onset of kidney failure; therefore a persistently reduced GFR is a specific diagnostic criterion for chronic kidney disease. Below 60 mL/min/1.73sq.m, the prevalence of complications of CKD increases, as does the risk of cardiovascular disease (CVD).

What is the significance of GFR measurement ?

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GFR is equal to the total of the filtration rates of the functioning nephrons in the kidney. In most healthy people, the normal GFR is 90 mL/min/1.73m2 or higher.
a result of 60-89 mL/min/1.73m2 without kidney damage may be normal in some people such as the elderly or infants (if, for example, there are no other findings indicative of kidney disease, such as protein in the urine).
a result of 60-89 mL/min/1.73m2 for => 3 months, along with kidney damage (such as persistent protein in the urine), means the person has early kidney disease.
When GFR is < 60 for => 3 months, chronic kidney disease (CKD) is present.

Measurement of glomerular filtration rate

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GFR is measured using plasma or urinary clearance of an exogenous filtration marker. However, this is a complex procedure and generally not routinely performed. Therefore, GFR is usually estimated from the person's serum creatinine level, in combination with demographic factor such as age, race, and gender using various formulas.

The importance of glomerular filtration rate

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GFR (glomerular filtration rate) is the optimal way to measure kidney function and determine a person's stage of kidney disease. The level of GFR and its magnitude of change over time are vital to :
the detection of kidney disease
understanding its severity
making decisions about diagnosis, prognosis and treatment

2013/06/22

Kidney Cancer problem

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The growth of a tumor in the kidney, either cancerous or benign, can cause tremendous damage to the structures of the kidney. A typical adult kidney measures approximately 10 centimeters by 5 centimeters, yet tumors within the kidney can reach 10 centimeters in diameter or larger before the patient feels the slightest effects.

By the time the tumor is found, even if it is non-cancerous, the kidney may no longer be functioning. In some cases, the damage is so severe that the kidney must be removed to prevent damage to other organs, including the heart. If the remaining kidney is also not functioning well, dialysis or a kidney transplant may be required.

You may have no symptoms at first. They may appear as the cancer grows. See your health care provider if you notice :
Blood in your urine
A lump in your abdomen and pain in your side that does not go away
Loss of appetite and weight loss