Normal GFR varies according to age, sex, and body size; in young adults it is approximately 120-130 mL/min/1.73m2 and declines normally with age. However, a decrease in GFR may also be a marker of kidney disease and precedes the onset of kidney failure; therefore a persistently reduced GFR is a specific diagnostic criterion for chronic kidney disease. Below 60 mL/min/1.73sq.m, the prevalence of complications of CKD increases, as does the risk of cardiovascular disease (CVD).
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