Figure 1 Figure 2
The increasing number of patients who suffer from chronic kidney diseases combined with the organ shortage have directed the attention of researchers to new alternatives in the fields of regenerative medicine including cell-based therapies and tissue bioengineering. This review of renal regenerative medicine addresses the mechanisms of action by stem cells to regenerate or repair chronically damaged renal tissue, alternative routes for their delivery, the role of biomaterials in tissue engineering, and the potential therapeutic effects of combining cell therapy with biomaterials. Despite the promise of ongoing work for therapy of chronic renal failure, caution is required as a large gap still exists between scientific knowledge and clinical translation for safe, effective stem cell-based therapies.
Figure 1 : Histology of experimental chronic renal failure included after 5/6 renal mass reduction. Severe interstitial fibrosis and glomerulosclerosis.
Figure 2 : Histology of experimental chronic renal failure after treatment with biomaterial seeded with 8 units of mesenchymal stem cells. Mild interstitial fibrosis and glomerulosclerosis and tubular degeneration.
